|Improves pain and function.
46 out of 100 are helped at least a little
23 out of 100 people are helped a lot
|Side effects and adverse events include nausea, hair loss, infections, liver toxicity.
10 out of 100 people had to stop methotrexate due to side effects
|Slows progress of disease.
70 out of 100 people show less joint damage on x-ray
|Extra clinic visits and blood tests needed.|
|Relatively low cost compared to other RA medications.||Affects development of the baby during pregnancy, so must stop methotrexate at least 3 months before attempting to get pregnant.|
Used with permission from John Wiley & Sons, Ltd.
Suarez-Almazor ME, Belseck E, Shea BJ, Tugwell P, Wells G. Methotrexate for treating rheumatoid arthritis. The Cochrane Collaboration. 2009, Issue 3.